Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax3  paired box 3   (Synonyms: Pax-3, Splchl2)
Results	Reference
1*	J:19895 Ang SL, Rossant J, HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
1*	J:81313 Bajanca F, Thorsteinsdottir S, Integrin expression patterns during early limb muscle development in the mouse. Mech Dev. 2002 Dec;119 Suppl 1:S131-4
1*	J:17224 Bober E, Franz T, Arnold HH, Gruss P, Tremblay P, Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development. 1994 Mar;120(3):603-12
1*	J:55248 Borycki AG, Li J, Jin F, Emerson CP, Epstein JA, Pax3 functions in cell survival and in pax7 regulation. Development. 1999 Apr;126(8):1665-74
1*	J:21616 Braun T, Bober E, Rudnicki MA, Jaenisch R, Arnold HH, MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Development. 1994 Nov;120(11):3083-92
1	J:87223 Buttitta L, Mo R, Hui CC, Fan CM, Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development. 2003 Dec;130(25):6233-43
1*	J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
1	J:35802 Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA, Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996 Oct 3;383(6599):407-13
1*	J:32016 Daston G, Lamar E, Olivier M, Goulding M, Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 1996 Mar;122(3):1017-27
1*	J:56236 Dickman ED, Rogers R, Conway SJ, Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant: putative roles for Pax3 and PDGFRalpha in rib patterning. Anat Rec. 1999 Jul 1;255(3):353-61
1*	J:16484 Dietrich S, Schubert FR, Gruss P, Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev. 1993 Dec;44(2-3):189-207
1*	J:55575 Furumoto TA, Miura N, Akasaka T, Mizutani-Koseki Y, Sudo H, Fukuda K , Maekawa M , Yuasa S , Fu Y , Moriya H , Taniguchi M , Imai K , Dahl E , Balling R , Pavlova M , Gossler A , Koseki H, Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev Biol. 1999 Jun 1;210(1):15-29
1	J:54101 Galceran J, Farinas I, Depew MJ, Clevers H, Grosschedl R, Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev. 1999 Mar 15;13(6):709-17
1*	J:44237 Goh KL, Yang JT, Hynes RO, Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997 Nov;124(21):4309-19
1*	J:11140 Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P, Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J. 1991 May;10(5):1135-47
1*	J:30824 Grass S, Arnold HH, Braun T, Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development. 1996 Jan;122(1):141-50
1*	J:65743 Harrison SM, Houzelstein D, Dunwoodie SL, Beddington RS, Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
1*	J:106931 Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H, Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol. 2006 Apr;26(7):2758-71
1*	J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1*	J:79898 Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA, The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 1;251(1):157-66
1*	J:73781 Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu LY, Liu YH, Ishii M, Sangiorgi FO, Rauchman M, Sucov HM, Maas RL, Maxson RE Jr, Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development. 2002 Jan;129(2):527-38
1	J:121554 Martinelli DC, Fan CM, Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007 May 15;21(10):1231-43
1	J:95326 McDermott A, Gustafsson M, Elsam T, Hui CC, Emerson CP Jr, Borycki AG, Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development. 2005 Jan;132(2):345-57
1*	J:103937 Murakami M, Tominaga J, Makita R, Uchijima Y, Kurihara Y, Nakagawa O, Asano T, Kurihara H, Transcriptional activity of Pax3 is co-activated by TAZ. Biochem Biophys Res Commun. 2006 Jan 13;339(2):533-9
1*	J:170532 Pan H, Gustafsson MK, Aruga J, Tiedken JJ, Chen JC, Emerson CP Jr, A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. Dev Biol. 2011 Mar 1;351(1):120-7
1*	J:31131 Pfaff SL, Mendelsohn M, Stewart CL, Edlund T, Jessell TM, Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996 Jan 26;84(2):309-20
1	J:64989 Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC, An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 2000 Sep 28;407(6803):535-8
1	J:169829 Pyrgaki C, Liu A, Niswander L, Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 2011 May 1;353(1):38-49
1*	J:18543 Rashbass P, Wilson V, Rosen B, Beddington RS, Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos. Int J Dev Biol. 1994 Mar;38(1):35-44
1	J:342640 Sampath Kumar A, Tian L, Bolondi A, Hernandez AA, Stickels R, Kretzmer H, Murray E, Wittler L, Walther M, Barakat G, Haut L, Elkabetz Y, Macosko EZ, Guignard L, Chen F, Meissner A, Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nat Genet. 2023 Jul;55(7):1176-1185
1	J:231654 Sanchez-Ferras O, Bernas G, Farnos O, Toure AM, Souchkova O, Pilon N, A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network. Development. 2016 Apr 15;143(8):1363-74
1*	J:316987 Sanchez-Ferras O, Coutaud B, Djavanbakht Samani T, Tremblay I, Souchkova O, Pilon N, Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer. J Biol Chem. 2012 May 11;287(20):16623-35
1*	J:87381 Schmidtmer J, Engelkamp D, Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr Patterns. 2004 Jan;4(1):105-10
1*	J:33032 Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ, Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature. 1996 May 16;381(6579):235-8
1*	J:72525 Schubert FR, Tremblay P, Mansouri A, Faisst AM, Kammandel B, Lumsden A, Gruss P, Dietrich S, Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. Dev Dyn. 2001 Nov;222(3):506-21
1	J:166526 Shum AS, Tang LS, Copp AJ, Roelink H, Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube. Dev Dyn. 2010 Dec;239(12):3192-203
1	J:201612 Takeda S, Liu H, Sasagawa S, Dong Y, Trainor PA, Cheng EH, Hsieh JJ, HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. J Clin Invest. 2013 Jul 1;123(7):3154-65
1	J:217059 Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H, Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8
1*	J:60178 Uchiyama K, Ishikawa A, Hanaoka K, Expression of lbx1 involved in the hypaxial musculature formation of the mouse embryo. J Exp Zool. 2000 Feb 15;286(3):270-9
1	J:138404 Vincentz JW, Barnes RM, Rodgers R, Firulli BA, Conway SJ, Firulli AB, An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol. 2008 Aug 1;320(1):131-9
1	J:59271 Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP, T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev. 1999 Dec 15;13(24):3185-90
1*	J:53289 Yang X, Castilla LH, Xu X, Li C, Gotay J, Weinstein M, Liu PP, Deng CX, Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
1	J:206311 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ, beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan;141(1):148-57